Professor Darren Griffin

Professor of Genetics
Director, Centre for Interdisciplinary Studies of Reproduction

About

Professor Darren Griffin joined the school in 2004 from Brunel University. His main interests are in the study of chromosomes, principally in humans (from spermatogenesis to preimplantation development) and birds. Other interests include allelic variation and its relationship to fatness and studies relating to eLearning. In 2007 he became a BBSRC Career Development Fellow with a remit to exploit microarray technology for studies of copy number variation in birds and humans.
Darren is a member of the Centre for Interdisciplinary Studies of Reproduction (CISoR)
He also regularly coordinates the International Chromosome Conferences.
Research Career 

  • 2008 Doctor of Science, University of Manchester 
  •  2007 Fellow of the Royal College of Pathologists 
  • 2007 BBSRC Career Development Fellow 
  • 2004 Vice President of the International Chromosome and Genome Society 
  • 2002 Postgraduate Certificate, Teaching and Learning in HE, Brunel University. 
  • 2002 Fellow of the Institute of Biology. 
  • 2001 Editorial Board 'Prenatal Diagnosis'. 
  • 1992 Doctor of Philosophy, Human Genetics, University College London. 
  • 1988 Bachelor of Science (with honours), Genetics and Cell Biology, University of Manchester. 

Research interests

Chromosome Segregation in Human Sperm and Preimplantation Embryos 

It is now well established that men with severely compromised semen parameters can have increased levels of aneuploidy in their sperm. We are interested in fundamental investigations into this phenomenon, in particular, the role of genetic recombination and changes in genome organisation. 

Through deeper understanding this we aim to better comprehend the causes of male fertility and the mechanisms of chromosome non-disjunction. We have evidence of the efficacy of Chinese Herbal Medicine in decreasing high aneuploidy rates in infertile men and for anti-oestrogenic properties in the medicinal herbs. Work has recently re-visited examination of the human preimplanatation embryo with research into the degree to which aneuploidy is transmitted from sperm to embryo and the role of genome organization in preimplantation development. We have close links with the London Bridge Fertility Clinic and Bridge Genoma.

Current projects:

Comparative Genomics of Avian Species 
The ability to distinguish each chicken chromosome has a number of applications in comparative genomics, developmental biology, molecular ecology, genome organization, and agriculture. We have developed resources that enable us to identify all chicken chromosomes individually. Work has now progressed to generating cytogenetic maps in a range of avian species and studying the role of chromosome evolution in birds.

Computer based learning
Our newest research interest is in the generation, evaluation and dissemination of computer-based learning tools in genetics, cytogenetics and human reproduction. In 2002 we launched "Learning Interactive" a University spin off activity specializing in production, dissemination and sale of these computer-based learning materials.

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