Dr Jennifer Tullet
Lecturer in Biogerontology
School of Biosciences
- 01227 (82)7221
Jennifer joined the School of Biosciences in September 2014 after conducting postdoctoral research with Prof David Gems (University College London) and Prof Keith Blackwell (Harvard). Prior to that, she obtained her PhD from Imperial College London under the supervision of Prof Malcolm Parker. Jennifer's background covers ageing biology, transcriptional regulation and C. elegans genetics. Her research focuses on the molecules and processes that regulate lifespan and influence life-long health.
- 2014 School of Biosciences, University of Kent, Canterbury, Kent. Lecturer and group leader: C. elegans ageing laboratory.
- 2008-2014 The Institute of Healthy Ageing, University College London. Post Doctoral work with Prof David Gems: Molecular mechanisms that regulate ageing in C. elegans.
- 2005-2008 Joslin Diabetes Center, Harvard Medical School. Post Doctoral work with Prof Keith Blackwell: Regulation of the pro-longevity factor SKN-1 by insulin-like signalling in C. elegans.
- 2001-2005 Institute of Reproductive and Developmental Biology, Imperial College London.
PhD with Prof Malcolm Parker: Functional characterisation of the nuclear receptor co-repressor RIP140 in the ovary.
- 1997-2001 The University of Kent, Canterbury. BSc Honours First Class: Biochemistry with an industrial placement year at Roche Diagnostics, Penzberg, Germany.
Also view these in the Kent Academic Repository
Ageing is an important problem for human health and increased age is correlated with many of the debilitating conditions experienced and suffered by humans in later life such as Alzheimer's, Huntington's, muscle degeneration, diabetes and cardiovascular disease. I am interested in understanding the detailed molecular mechanisms via which ageing occurs.
I explain more about my research in the recent podcasts below:
It is difficult to study ageing in humans due to the time scales involved so, scientists use simpler organisms such as worms, flies and mice. My work uses the nematode worm C. elegans to understand the ageing process. This amazing, tiny worm (1mm long) lives for 3 weeks in the laboratory and has been vital to our understanding of ageing. It is possible to extend its lifespan either by changing its genetic makeup or by altering the environment in which it is grown. Importantly, interventions that extend lifespan also tend to protect against age-related pathologies so, we are not simply extending lifespan but also improving the quality of late-life health.
The molecules we study are also present in mammalian cells. So, by studying their effects on lifespan in worms, we will eventually be able to use this information to design interventions to slow ageing and improve the late-life health of humans.
Current, key research topics include;
- Understanding the roles of transcription factors in the regulation of ageing.
- Deciphering the relationship between diet and lifespan.
- Examining the role of energy balance in regulating lifespan.
- BI626 Integrated Endocrinology and Metabolism