Professor Darren Griffin
Professor of Genetics,
School of Biosciences
- 01227 (82)3022
Professor Darren Griffin joined the school in 2004 from Brunel University. His main interests are in the study of chromosomes, principally in humans (from spermatogenesis to preimplantation development) and birds. Other interests include allelic variation and its relationship to fatness and studies relating to eLearning. In 2007 he became a BBSRC Career Development Fellow with a remit to exploit microarray technology for studies of copy number variation in birds and humans.
Darren is a member of the Centre for Interdisciplinary Studies of Reproduction (CISoR)
He also regularly coordinates the International Chromosome Conferences.
The Pig Breeders Round Table this year will be held 22-23 April 2015 in Keynes College, University of Kent.
2008 Doctor of Science, University of Manchester
2007 Fellow of the Royal College of Pathologists
2007 BBSRC Career Development Fellow
2004 Vice President of the International Chromosome and Genome Society
2002 Postgraduate Certificate, Teaching and Learning in HE, Brunel University.
2002 Fellow of the Institute of Biology.
2001 Editorial Board 'Prenatal Diagnosis'.
1992 Doctor of Philosophy, Human Genetics, University College London.
1988 Bachelor of Science (with honours), Genetics and Cell Biology, University of Manchester.back to top
Also view these in the Kent Academic Repository
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Figure: Three colour FISH on human sperm. X chromosome (yellow), Y chromosome (green), chromosome 21 (red). Three sperm in this field of view are XY disomic.
Chromosome Segregation in Human Sperm and Preimplantation Embryos
It is now well established that men with severely compromised semen parameters can have increased levels of aneuploidy in their sperm. We are interested in fundamental investigations into this phenomenon, in particular, the role of genetic recombination and changes in genome organisation.
Through deeper understanding this we aim to better comprehend the causes of male fertility and the mechanisms of chromosome non-disjunction. We have evidence of the efficacy of Chinese Herbal Medicine in decreasing high aneuploidy rates in infertile men and for anti-oestrogenic properties in the medicinal herbs. Work has recently re-visited examination of the human preimplanatation embryo with research into the degree to which aneuploidy is transmitted from sperm to embryo and the role of genome organization in preimplantation development. We have close links with the London Bridge Fertility Clinic and Bridge Genoma.
Comparative Genomics of Avian Species
The ability to distinguish each chicken chromosome has a number of applications in comparative genomics, developmental biology, molecular ecology, genome organization, and agriculture. We have developed resources that enable us to identify all chicken chromosomes individually. Work has now progressed to generating cytogenetic maps in a range of avian species and studying the role of chromosome evolution in birds
Figure A: colour painting of chicken macrochromosomomes.
Figure B: Dual colour chromosome painting of 2 smallest chicken chromosomes (chromosomes 37 and 38)
The spin off activity FARMACHROM has arisen from this work, which provides resources to a range of international collaborators.
In both the above we are now investigating the role of microarray technology for the determination of copy number variation thanks to a recently awarded Career Development Fellowship
Our newest research interest is in the generation, evaluation and dissemination of computer-based learning tools in genetics, cytogenetics and human reproduction. In 2002 we launched "Learning Interactive" a University spin off activity specializing in production, dissemination and sale of these computer-based learning materials.
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