School of Biosciences

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Current PhD opportunities

The School of Biosciences is please to announce funding for a PhD studentship to start in September 2017.

Funding: The studentship will pay an annual stipend at the UK Research Council rate of £14,553 (rate for 2017/2018) and cover tuition fees at the rate for UK/ EU students. International applicants must make provision to meet the difference between Home and International fees.

To apply: Please submit an on-line application via the University application page enter the project title as the proposed research topic and Dr Mark Wass as the supervisor. For the research proposal please enter "as advertised". Please include a cv and a covering letter.

Deadline: 19 May 2017

Investigating host cell protein impurities in monoclonal antibody purification

Supervisor: Dr Mark Wass and Professor Daniel Bracewell UCL

The production of biotherapeutics, particularly monoclonal antibodies (mAbs) has a multi-billion dollar global market value. Their purification requires separation of the product from the biological impurities present after cell culture. This project focusses on the analysis of host cell proteins, are a challenging class of impurities that need to be controlled and reduced to ensure high levels of purity of the monoclonal antibody. Host cell proteins represent a significant problem in the purification process as they are diverse representing the range of different proteins present in the host cell.

This project will combine computational approaches and wet laboratory experiments. The computational analysis will investigate how host cell proteins interact with monoclonal antibodies and to identify modifications to purification processes that will reduce the level of host cell protein impurities. This will be followed up by wet laboratory experiments to validate the findings of the computational research.

The project will be supervised by Dr Mark Wass (University of Kent) and Prof Daniel Bracewell (UCL). The student will primarily be based in the School of Biosciences at the University of Kent and some elements of the project will be completed at UCL.

Informal enquiries can be addressed to Dr Mark Wass (m.n.wass@kent.ac.uk) or Prof Daniel Bracewell (d.bracewell@ucl.ac.uk).

Entry requirements: Given the interdisciplinary nature of this project it is best suited to a student who has some experience of wet laboratory research and bioinformatics or computing. All candidates are expected to have a minimum of an upper 2nd class degree in an appropriate field.

Funding: The studentship will pay an annual stipend at the UK Research Council rate of £14,553 (rate for 2017/2018) and cover tuition fees at the rate for UK/ EU students. To be eligible for a full award a student must have no restrictions on how long they can stay in the UK and have been ordinarily resident in the UK for at least 3 years prior to the start of the studentship.

For further information please contact Dr Mark Wass

How to apply:This is a four year EPSRC funded project with a stipend at Standard Research Council rates (£14,553 for 2017/18). Applications can be made online at https://www.kent.ac.uk/courses/postgraduate/1202/computational-biology where the project title should be entered as the proposed area of research and Dr Mark Wass as supervisor.
Please include a CV and cover letter explaining your interest in the project.

Deadline Date for Applications: 19 May 2017
Interviews will take place at the University of Kent on 31 May 2017.

 

 

 

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Enquiries: Phone: +44 (0)1227 823743

School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ

Last Updated: 05/05/2017