Cytogenomics and Bioinformatics Group
The Cytogenomics and Bioinformatics group, and associated Chromonomics Laboratory, work collectively to focus on research that has practical and therapeutic applications in prognosis, prediction, diagnosis and treatment of disease. This includes fundamental investigations into the formation and behaviour of chromosomes at mitosis and meiosis helps exploit the interface with genomics to study genome evolution, selection, structure, inheritance and reproductive medicine. This is coupled closely with high performance computational methods that have been generated to allow analysis of databases and inheritance patterns.
“Chromonomics” is the term we like to use for the interface between chromosome research and the study of whole genome sequences. The laboratory focuses in three main area:
1. the study of the relationship between chromosome abnormalities, fertility, IVF failure and pregnancy loss in human gametes and embryos
2. the use of pig as a model for studying the genetic basis of human disease
3. the study of the evolution and genome structure of birds
The work has a strong applied element being translated into agriculturally relevant products and knowledge the development of novel tools for the diagnosis of genetic disease in IVF embryos. With colleagues at the London Bridge Fertility Centre the lab was shortlisted for research project of the year (2010) by the Times Higher Education Supplement.