School of Biosciences

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The Wellcome Trust Biomolecular NMR Facility

 

The research

Biomolecular NMR based research at the University of Kent

Research within the NMR facility covers many areas and disciplines across the School of Biosciences and through external collaborations.  These include: The facility

  • structural characterisation of biochemically and biomedically relevant biomolecules
  • investigation of the dynamic properties of proteins and peptides using NMR relaxation
  • characterisation of protein-ligand interactions
  • high resolution spectroscopy of intermediates from biosynthetic pathways
  • identification of components in crude biological samples
  • design of novel NMR and structural methodologies
  • applied computational methods and software development for both NMR and structural biology

NMR studies of proteins, peptides, nucleic acids and chemical fragments provide a common workload for the spectrometer. Experiments vary from unlabelled samples or isotopically enriched samples incorporating [15N], [13C], [15N, 13C] or [2H, 15N, 13C].

Peptides and proteins ranging in molecular weight from 2 kDa to in excess of 50 kDa are routinely studied. The facility is a centre of excellence for saturation transfer NMR and other methods of identifying protein-ligand interaction and epitope mapping information.

We offer state-of-the-art homonuclear and heteronuclear, one- and multi-dimensional NMR spectroscopy on the following systems:

  • Compounds
  • Metabolic precursors
  • Peptides
  • Proteins
  • Nucleic Acids
  • Biofluids and metabolic mixtures
  • Cell extracts and whole cell NMR
  • Ligand-Target Screening
Collaborative Principle Investigators at Kent: External Collaborations

Dr. Mark Howard
Dr. Richard Williamson
Prof. Martin Warren
Prof. Mick Tuite
Prof. Mark Smales
Dr. Campbell Gourlay
Dr. Tobias von der Haar
Dr Ben Goult
Dr. Tim Hopkins (Computing)
Mr. David Barnes (Computing)

Prof. Robert Freedman (Warwick)
Prof. Lloyd Ruddock (Oulu, Finland)
Dr Helen Walden (London Research Institute)
Dr. John Marshall (QMUL, Barts Cancer Institute, London)
   
 

 

 

 

Enquiries: Phone: +44 (0)1227 823743

School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ

Last Updated: 09/01/2017