Dr Stefanie Frank
Leverhulme Early Career Fellowship
School of Biosciences
- 01227 82(4692)
Stefanie obtained her MSc in 2001 from the Friedrich-Schiller University Jena (Germany) and went on to work in the group of Prof David Becker (University College London) investigating the role of gap-junctional communication in wound healing. Stefanie joined Prof Martin Warren's group (Queen Mary University of London) as a PhD student in 2003 where she developed an interest in pathway engineering while investigating the mechanisms of enzymes along the anaerobic vitamin B12 synthesis route. The group moved to the University of Kent in 2005 where Stefanie completed her PhD in 2007. She continued onto a post-doctoral position where she investigated bacterial compartmentalization of pathways.
In June 2013, Stefanie was awarded a Leverhulme Early Career Fellowship, enabling her to work on the engineering of bacterial microcompartments for recombinant protein production.back to top
Also view these in the Kent Academic Repository
My research interests include prokaryotic compartmentalisation, macromolecular assemblies, protein-protein interactions, protein structure/function, metabolic pathway engineering, synthetic biology and imaging.
Bacterial microcompartments (BMC) are large macromolecular protein assemblies that facilitate the separation of metabolic processes from other activities in the cell in order to avoid cell damage through toxic intermediates and improve pathway efficiency. I am particularly interested in the function, assembly and spatial arrangement of such bacterial microcompartments and their potential for biotechnological applications. My work is based on engineering recombinant microcompartments in E. coli. I use molecular biology, biochemistry and microscopy (TEM, AFM, live cell imaging) methods to study and manipulate the composition of microcompartments with the idea to direct specific enzymes to the BMC and to produce bioreactors, that are adaptable for specific metabolic processes.back to top
Membership/administrative role on committees:
- 2013 Researcher Development Working Group (RDWG) (faculty representative)