Metabolism and Metabolic Disease - BI520

Location Term Level Credits (ECTS) Current Convenor 2019-20
Canterbury Autumn
View Timetable
5 15 (7.5) DR A Lawrence

Pre-requisites

Prerequisite:
First year core modules for BSc Biochemistry or BSc Biomedical Science

Restrictions

Stage 2 students only

2019-20

Overview

This module covers the general principles of metabolic disorders and focuses on pathways, enzyme mechanisms, and diseases associated with:
Energy metabolism
Amino acid/nucleotide metabolism
The urea cycle
Cholesterol metabolism
Vitamin metabolism
Heme synthesis/breakdown

Details

This module appears in:


Contact hours

Total contact hours: 23
Private study hours: 127
Total study hours: 150

Availability

It is recommended that you have taken core Stage 1 modules in Biochemistry or Biomedical Sciences

Method of assessment

MCQ Test (20%)
Computer practical report (20%) – 2000 words
Exam, 2 hr, (60%)

Indicative reading

Core Text:
Nelson DL, Lehninger Principles of Biochemistry. Editions 5 – 7.
Selected articles from scientific journals may also be recommended.

Recommended Reading:
Clarke, Joe T. R., A Clinical Guide to Inherited Metabolic Diseases. Cambridge: Cambridge University Press, 2006. 3rd ed. e-book edition (via library catalogue).
Osgood M, Ocorr KA, The Absolute, Ultimate Guide to Lehninger Principles of Biochemistry: Study Guide and Solutions Manual, 6th edition, W.H. Freeman, 2012.
Newsholme and Leech, Functional Biochemistry in Health and Disease. Chichester; Wiley, 2009. Hardcopies and e-book (via library catalogue).

See the library reading list for this module (Canterbury)

Learning outcomes

The intended subject specific learning outcomes.
On successfully completing the module students will be able to:
Understand selected mechanisms that can lead to human metabolic diseases, and their genetic basis.
Recall metabolic maps that relate the main pathways of catabolism and biosynthesis to each other.
Understand how metabolic pathways interact with each other, including those in different tissues.
Understand selected chemical mechanisms that underpin the metabolism studied.

The intended generic learning outcomes.
On successfully completing the module students will have:
Written and oral communication skills.
Skills to analyse data relating to metabolic defects and report results.
Problem solving skills.

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