Rapid advances in our understanding of how cell work and the use of novel genetic toolkits have led to new treatment avenues for diseases that were considered life sentences until just recently. This module examines the key elements of gene expression and how the development of gene expression systems has contributed to the growth of biotherapeutics. It also describes the different types of biotherapeutics (such as the different peptide and complex proteins currently licensed and the difference between biologics and biosimilars). Additionally, the module briefly explores nucleic acids in the context of how they can selectively modulate gene expression or how they can be used as vaccines. Finally, the module will briefly review the different types of DNA sequence variation, how individual genetic variation can now be detected and why pharmacogenetics is an important discipline in term of predicting responses to drugs.
Blended distance learning:
Contact Hours: 100 hours
Private Study Time: 50 hours
Total Learning Time: 150 hours
Written Assignment (2,000 words) – 40%
3 hour Examination – 60%
All assessments must be passed in order to pass the module.
See the library reading list for this module (Medway)
The intended subject specific learning outcomes.
Describe the architecture of the human genome, including both coding and non-coding elements.
Describe the main types of DNA sequence variation (for example, single nucleotide variants (SNVs) and small insertions and deletions (indels), how these may be associated with risks of adverse response or drug response and demonstrate a knowledge of the methods used to identify DNA sequence variations.
Demonstrate a critical understanding the key steps and players in control of gene expression.
Demonstrate a critical understanding of how the key steps and players in control of gene expression can be manipulated in different host systems or in-vitro, including considerations around productivity, scalability and purity.
Understand the differences between the different types of biotherapeutics and current methods to increase their efficacy and homogeneity, and current methods of delivery..
Critically appraise research and clinical applications around the development of biotherapeutics.
The intended generic learning outcomes.
Develop and demonstrate an ability to analyse, evaluate and correctly interpret data.
Present and communicate data effectively and confidently.
Obtain and use information from a variety of sources as part of self-directed learning.
Manage their time and use their organisation skills within the context of self-directed learning.
Develop and demonstrate an ability to communicate effectively with others.
University of Kent makes every effort to ensure that module information is accurate for the relevant academic session and to provide educational services as described. However, courses, services and other matters may be subject to change. Please read our full disclaimer.
