Transformations and Chirality in Organic Chemistry - CH624

Location Term Level Credits (ECTS) Current Convenor 2018-19 2019-20
Canterbury Autumn and Spring
View Timetable
6 15 (7.5) DR CJ Serpell

Pre-requisites

CH309 CH382/PS381, and CH314 as prerequisite; CH506 as co-requisite.

Restrictions

None

2018-19

Overview

A key component to chemical education is the exposure to more advanced aspects of chirality, and chemical transformations towards the synthesis of simple targets. Concepts relating to the synthesis of natural and unnatural target molecules through organic chemical transformations are essential to the students’ chemical repertoire. In-depth exposure to chirality, exposure to asymmetric chemical transformations, carbon-carbon bond-forming reactions, and their application in targeted small molecule synthesis will be covered.

Details

This module appears in:


Contact hours

24 hours of lectures, 3 individual assignments in 3 workshop sessions (3 hrs each); total study hours: 150

Availability

This is not available as a wild module.

Method of assessment

Three Assignments (10%, 15%, 15%). Each assignment will comprise two parts. Workshops will address particular problem solving approaches with a mandatory submission (part A), followed by a separate submission following the workshop (part B).

Preliminary reading

Primary: G. Solomons, Organic Chemistry 11th Ed.

  • Principles of Asymmetric Synthesis by Gawley, and Aube
  • Secondary: Clayden, Geeves, Organic Chemistry 2nd Ed.
  • selections of primary journal literature will be provided

    See the library reading list for this module (Canterbury)

    See the library reading list for this module (Medway)

  • Learning outcomes

    Knowledge and understanding of:

  • Core and foundation scientific chemical, concepts, terminology, theory, and methods in relation to the chemical sciences.
  • Areas of chemistry including properties of chemical elements, organic functional groups, physiochemical principles, organic and inorganic materials, and synthetic pathways.
  • Appreciate developments at the forefront of some areas of chemical sciences.

    Intellectual skills:
  • Ability to demonstrate knowledge and understanding of essential facts, concepts, principles and theories relating to the subject and to apply such knowledge and understanding to the solution of qualitative and quantitative problems.
  • Ability to recognise and analyse problems and plan strategies for their solution by the evaluation, interpretation and synthesis of scientific information and data.

    Subject-specific skills:
  • The ability to collate, interpret and explain the significance and underlying theory of experimental data pertaining to: classes of chirality and chirality resolution; chiral synthesis: carbonyls, auxiliaries, protecting groups, oxidation, enolate and aldol reactions; chemistry of double bonds: Diels Alder, frontier orbital theory, Woodward Hoffman rules; classical heterocyclic synthesis: Fischer Indole, cytosine and pyridine; targeted synthesis of topical organic molecules: squalene and Cholesterol.

  • Communication skills, covering both written and oral communication.
  • Generic skills needed for students to undertake further training of a professional nature.
  • Problem-solving skills, relating to qualitative and quantitative information, extending to situations where evaluations have to be made on the basis of limited information.
  • Time-management and organisational skills, as evidenced by the ability to plan and implement efficient and effective modes of working. Self-management and organisational skills with the capacity to support life-long learning.

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