Dr James Budge

Dr James Budge’s lab focuses on the mechanisms governing nucleic acid delivery and expression in mammalian cells, with the aim of developing next-generation technologies for gene therapy production and recombinant biologics manufacturing. His work spans mammalian cell engineering, transfection biology, cell line development and bioprocess optimisation, with a particular focus on improving the efficiency, robustness and scalability of therapeutic production platforms. 

Prior to his academic appointment, James established an extensive research portfolio through collaborations with industrial partners leading projects focused on host cell engineering, expression system development and biomanufacturing innovation. His research has generated patented technologies, novel molecular tools and commercially relevant bioprocessing solutions. He has published widely in the fields of cell engineering, biotechnology and bioprocessing and regularly presents his work at major international conferences. 

As Principal Investigator, James is developing a research programme focused on understanding how cellular processes influence nucleic acid delivery, gene expression and therapeutic manufacturing, with the long-term goal of enabling more effective and accessible therapies. 

James’ key research interests are: 

• Gene therapy bioprocessing and manufacturing
• Nucleic acid delivery and therapeutic technologies
• Mammalian cell and cell engineering
• Cell line development and expression systems
• Recombinant biologics and advanced therapeutic production
• Industrial biotechnology and bioprocess innovation 

James' research combines molecular engineering, cell biology and bioprocessing to address challenges associated with the development and manufacture of advanced therapeutics. Using approaches that span cell line engineering, microscopy, flow cytometry and molecular analysis, his work seeks to understand the mechanisms governing nucleic acid delivery, gene expression and cellular productivity. Working closely with both academic and industrial collaborators, he develops innovative technologies that bridge fundamental biological understanding with practical manufacturing solutions for gene therapies, nucleic acid medicines and recombinant biologics.  

• BIOS5510- Bioscience Skills: Developing as an Independent Scientist 
• BIOS6120- Proteins: Structure, Function and Analysis 
• BIOS7009- Pathogen Diagnosis, Therapeutics, and Vaccines 
• BIOS7010- Biotechnology in Action 
• BIOS7011- Cutting Edge Research Developments in Biotechnology (Module Convenor) 
• BIOS7012- Advanced Analytical and Emerging Technologies for Biotechnology and Bioengineering  

• ESACT Frontiers Committee Position