Researchers used urinary ‘finger-printing’ to determine the effects of three ‘healthy’ diets on volunteers with moderately high blood pressure. The method allowed researchers to evaluate individual responses to carbohydrate-rich, protein-rich and monounsaturated fat-rich diets and monitor how closely the volunteers followed the diet.
The research suggests that there is the potential for the development of treatment plans for high blood pressure that take into account the metabolic and microbiological background of the individual.
Dr Ruey Leng Loo, of Kent’s Medway School of Pharmacy, working in a team with researchers from Imperial College London and Johns Hopkins University in the US, studied urine samples from 158 study participants.
The researchers found that each of the three healthy diets generally produced reduced blood pressure in most of the participants but that a small proportion of individuals responded less well to healthy diets. This was found to be due to individual differences in their gut bacteria, which were detected by identifying bacterial metabolites in the urine.
Dr Loo said that, although further research was needed, it would be feasible in the future for diabetologists, cardiologists and dieticians to adopt a new approach in identifying an individuals’ clinical response to diet therapy, as well their adherence to prescribed diets.
The study, entitled Characterization of metabolic responses to healthy diets and the association with blood pressure: application to the Optimal Macronutrient Intake Trial for Heart Health (OmniHeart), a randomized control study (Ruey Leng Loo, Xin Zou (both Medway School of Pharmacy, universities of Kent and Greenwich; Laurence J Appel, Johns Hopkins University; Jeremy Nicholson and Elaine Holmes, Imperial College London) is published in The American Journal of Clinical Nutrition.