This module is not currently running in 2024 to 2025.
This module aims to provide students with a detailed knowledge and deep understanding of the formulation of solid dosage forms, powder technology and other pharmaceutical factors affecting the manufacture and delivery of oral dosage forms. Students will develop a critical understanding of key aspects of physiochemical and biopharmaceutical properties of drug substances. In addition, the module will cover key concepts and principles of pharmacokinetics and drug metabolism. Instrumental analytical methods used in a pharmaceutical context and their bases in theory will be strengthened by giving students practical experience of using a variety of analytical instruments in exploring selected pharmaceutical applications.
Lectures (45 hours), Practical/Workshop (45 hours), MSCL/CAL (97 hours), Seminars (10 hours), Private Study (100 hours expected)
60% examination, 40% continuous assessment and satisfactory attendance and performance at all scheduled coursework sessions (workshops and laboratories).
Aulton, M.E. (2001) Pharmaceutics - The Science of Dosage Form Design, Churchill-Livingstone
Banker, G.S. & Rhodes, C.T. (2002) Modern Pharmaceutics (Drugs & the Pharmaceutical Sciences S.), Marcel Dekker Ltd
Florence, A.T. & Attwood, D. (2005) Physiochemical Principles of Pharmacy, Pharmaceutical Press
Shargel, L. & Yu, A.B.C. (2004) Applied biopharmaceutics and pharmacokinetics, Appleton and Lange
Thomas, G. (2000) Medicinal Chemistry - An Introduction, Wiley
Watson, D.G. (2005) Pharmaceutical Analysis: A Textbook of Pharmacy Students Pharmaceutical Chemists, Churchill-Livingstone
Williams, D.A., Foye, W.O. & Lemke, T.L. (2002) Foye's Principles of Medicinal Chemistry
An ability to discuss powder technology in pharmaceutical manufacture and measure various properties of powders (PO7, PO48, PO49, PO53)
An ability to apply their knowledge of preformulation properties and powder technology to the formulation of proprietary dosage forms discussed in this module and the manufacturing processes involved in the preparation of these dosage forms (PO6, PO7, PO8, PO11, PO12, PO24, PO48, PO49, PO50, PO52, PO53, PO54)
A deep understanding of how drugs are absorbed from various formulations, the physiological and physico-chemical factors which modify the process and an ability to describe how drugs are distributed, metabolised and eliminated from the body. (PO4, PO8, PO17, PO18)
An ability to interpret pharmacokinetic data and extract specific pharmacokinetic parameters from given data (PO4, PO18, PO48)
A deep understanding of the theoretical basis of spectroscopic and chromatographic methods (PO1, PO3, PO48, PO54, PO55)
An ability to correctly use extraction, purification and pharmaceutical analysis methods for identification and quantification of pharmaceuticals (PO1, PO3, PO51, PO53, PO54, PO55)
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