The module deals with the molecular mechanisms of gene expression and its regulation in organisms ranging from viruses to man. This involves descriptions of how genetic information is stored in DNA and RNA, how that information is decoded by the cell and how this flow of information is controlled in response to changes in environment or developmental stage. Throughout, the mechanisms in prokaryotes and eukaryotes will be compared and contrasted and will touch on the latest developments in how we can analyse gene expression, and what these developments have revealed.
Total contact hours: 30
Private study hours: 120
Total study hours: 150
Assignment 1, word limit 750-1000 words (20%)
Assignment 2, word limit 1500-2000 words (20%)
Exam, 2 hr, (60%)
Core Texts (one of the following):
Krebs, J.E., Goldstein, E.S. and Kilpatrick, S.T. "Lewin's Genes XII", Jones and Bartlett Learning, Publishers, 2018 [ISBN-978-1-284104493]
Krebs, J.E., Goldstein, E.S., Kilpatrick, S.T. "Lewin's Essential Genes 3rd edition" Jones and Bartlett Learning, 2013, [ISBN: 978-1-4496-4479-6]
Watson, J.D., Baker, T.A., Bell, S.P., Gann, A., Levine, M. & Losick, R. "Molecular Biology of the Gene, 7th Edition", Pearson, 2014 [ISBN: 978-0-321-85149-9]
In addition, the following books are recommended for supplementary/background reading:
Craig, N., Cohen-Fix, O., Green, R., Greider, C., Storz, G., Wolberger, C. 'Molecular Biology: Principles of Genome Function', 2nd edition OUP Oxford; 2014, ISBN-13: 978-0198705970
Latchman, D.S. 'Gene Control'. Garland Science, 2014, ISBN-10: 0815365136
See the library reading list for this module (Canterbury)
The intended subject specific learning outcomes. On successfully completing the module students will be able to:
Demonstrate an understanding of how genes are organised, expressed and controlled in both prokaryotes and eukaryotes.
Demonstrate an awareness of the contribution of modern molecular and cellular technologies in furthering our understanding of gene expression and its control.
Demonstrate an appreciation of the importance of fundamental research into gene structure and function for future developments in the fields of human genomics and disease.
Analyse data from laboratory experiments that address issues relating to gene structure and/or expression.
The intended generic learning outcomes.
On successfully completing the module students will be able to:
Extract and interpret information at an intermediate level.
Analyse and evaluate experimental data at an intermediate level.
Have acquired skills in written communication and receiving critique.
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