CCNCS Seminar Details
Prospective memory deficits along the schizophrenia spectrum disorders
|Speaker:||Professor Raymond Chan|
|Date/Time:||Wednesday 7 December 2011, 3.00pm|
Memory impairment is one of the core deficits in schizophrenia. This study explored the memory profiles, prospective memory in particular, of schizophrenic and psychometrically defined schizotypal subjects. The first study participants included 15 patients with schizophrenia, 41 schizotypal subjects, and 20 healthy controls. The results showed that patients with schizophrenia were impaired in all aspects of memory function, whereas the schizotypal subjects tended to show moderate to large impairment effect sizes in prospective memory. The second was to explore the relationship between computer-based prospective memory tasks and the corresponding subjective complaints in patients with schizophrenia, individuals with schizotypal personality features, and healthy volunteers. The findings showed that patients with schizophrenia demonstrated significantly poorer performances in all domains of memory functions except visual memory than individuals with SPD and healthy controls. More importantly, there was a significant interaction effect of prospective memory type and group. Although patients with schizophrenia were found to show significantly poorer performance on computer-based measures of prospective memory than controls, their level of subjective complaints was not found to be significantly higher. The third study examined the similar and differential prospective memory performances between schizophrenia and bipolar disorders. The final two studies adopted ERP and functional imaging paradigms to examine the underlying neural processing of prospective memory performances in individuals at-risk for psychosis. Taken together, these findings suggest that subjective and objective measures of prospective memory are two distinct domains that might need to be assessed and addressed separately, and that prospective memory may be considered a potential endophenotype of schizophrenia.