School of Physical Sciences

OCT/SLO

The OCT/SLO instrument was invented in 1998 by Adrian Podoleanu and David Jackson

Optical mapping apparatus with adjustable depth resolution
United States Patent 5975697 · Filed: 11/25/1998 · Published: 11/02/1999

A. Gh. Podoleanu D. A. Jackson      Combined Optical Coherence Tomograph and Scanning Laser Ophthalmoscope, Electronics Letters, Vol. 34, No. 11, (1998), pp. 1088-1090.
A. Gh.Podoleanu, D. A. Jackson, Noise Analysis of a Combined Optical Coherence Tomograph and a Confocal Scanning Ophthalmoscope,     Appl. Optics, Vol. 38, (1999), No. 10, pp. 2116 -   2127.
Our first OCT/SLO ever was an en-face OCT/SLO system, where the OCT channel operates based on en-face time domain OCT. After 2002, spectral domain OCT technology took off, and the SLO channel was then paired sequentially with a spectral domain OCT channel.
Such a system is now sold by Optos Plc., based on the patent
Optical imaging apparatus with spectral detector
United States Patent 7649629 B2 · Filed: 10/05/2007 · Published: 01/19/2010

The acronym OCT/SLO lives on meaning now different formats of OCT. Spectral domain OCT technology is now so fast, that a fundus image can be created using spectral domain OCT. Several groups have by now reported generation of a fundus type image to guide the B-scan imaging based by the spectral domain OCT, and labelled their instruments as OCT/SLO.


The animation below shows the output from a joint OCT/SLO system, with the SLO image on the left and the OCT on the right. The top of the optic nerve, then the RPE and at the end the lamina cribrosa are seen in the OCT image. In the SLO image, these are visible all the time. The animation is made up from forty 3 mm x 3 mm images collected from the optic nerve in 20 seconds, with a total exploration depth of 1.5 mm.

1

The images below show the assembly of a unique compact opthalmological imaging system capable en-face OCT/SLO as well as longitudinal SLO (collaboration with Ophthalmic Technology Inc Canada)

2

Dr. John Rogers assembles an OCT/SLO system

3

Other key publications on the OCT/SLO in the Applied Optics Group

No

Authors

Title of the Work

Journal or  volume

J112

R.B. Rosen,
M. Hathaway,
J. Rogers,
J. Pedro,
G. Patricia
P. Laissue,
G. M. Dobre,
A. Gh. Podoleanu

A. Gh. Podoleanu and R. B. Rosen contributed equally)

Multidimensional en-Face OCT imaging of the retina

Invited for the launch of the Interactive Science Publishing software, a novel approach in dissemination, where authors are given access to the raw data of the images presented
Optics Express, Vol. 17 Issue 5, pp.4112-4133 (2009)
doi:10.1364/OE.17.004112, ISSN: 1094-4087
Impact factor: 3.7

J105

A. Gh. Podoleanu
R. B. Rosen

Combinations of techniques in imaging the retina with high resolution

Invited review,
Progress in Retinal and Eye Research, 27, No. 4, (2008): 464-499
http://dx.doi.org/10.1016/j.preteyeres.2008.03.002, ISSN: 1350-9462
Impact factor: 7.7

J103

R. B Rosen
M.E.J. vanVelthoven
P.M.T. Garcia
R.G Cucu
M.D de Smet
T.O.Muldoon
A Gh Podoleanu

Ultrahigh-Resolution Combined Coronal Optical Coherence Tomography
Confocal Scanning Ophthalmoscope (OCT/SLO) : A pilot study

Spektrum Augenheilkd (2007) 21/1: 36–47
ISSIN, 0930-4282 (Print) 1613-7523 (Online)

J95

M. E. J. Van Velthoven
F. D.Verbraak
L. A. Yannuzzi
R. B. Rosen
A.Gh. Podoleanu
Marc D. De Smet,

Imaging the Retina by En-Face
Optical Coherence Tomography

Retina-the Journal of Retinal and Vitreous diseases, 26:pp. 129–136, 2006

J80

A.Gh.Podoleanu
G. M.Dobre
R. G. Cucu
R. Rosen
P. Garcia
J. Nieto
D. Will
R. Gentile
T. Muldoon
J. Walsh
L  A. Yannuzzi
Y. Fisher
D. Orlock
R Weitz
J. A. Rogers
S. Dunne
A.Boxer 

Combined Multiplanar Optical Coherence Tomography
and Confocal Scanning Ophthalmoscopy

 

Journal Biomedical Optics,
9(1), 86–93 (January/February 2004)
Impact factor: 3.1

J78

A.Gh.Podoleanu
R. Rosen
J. A. Rogers
G. M.Dobre
R. G. Cucu
D.A.Jackson
Shane Dunne

En-face optical coherence tomography in ophthalmology

University Politehnica Bucharest, Sci. Bull, Seriea A, Vol. 65, No. 1-4, 2003, 190-198.

J75

A. Gh. Podoleanu
J. A. Rogers
G. M. Dobre
R. G.  Cucu
D. A. Jackson
R Rosen, et all

Multi-planar  OCT/ Confocal Ophthalmoscope in the Clinic

Ophthalmic Research,
Supplement,
Karger, Basel, 2002
ISSN 0030-3747
EVER 2002, p.112.

High axial resolution en-face OCT channel combined with SLO


J97

R. G. Cucu
A.Gh. Podoleanu. A. Rogers
J. Pedro
R. B. Rosen

C ombined confocal scanning ophthalmoscopy/en face T-scan based ultrahigh resolution OCT of the human retina in vivo

Optics Letters, Vol. 31, No. 11, June 1, 2006, 1684-1687.
ISSN: 0146-9592

Other possible combinations refer to sequential or quasi sequential regimes of operation of the en-face OCT with SLO

Sequential, instead of simultaneous, acquisition allows all the signal to be used in each of the channels (collaboration with New York eye and Ear Infirmary) as per entries in the list below.


J106

I. Trifanov
M. Hughes
R. B. Rosen
A. G. Podoleanu

 Quasi-simultaneous OCT/confocal imaging

Journal of Biomedical Optics, 13(4), 044015 (July 18 2008)
044015-1 to 044015-7.
ISSN: 1083-3668
Impact factor: 3.1

J81

A.Gh.Podoleanu
G. M.Dobre
R. G. Cucu
R. Rosen

Sequential OCT and Confocal Imaging

Opt. Letters, 29 (4): 364-366 Feb. 15 2004
http://www.opticsinfobase.org/abstract.cfm?id=78717

J77

A.Gh. Podoleanu
R. G. Cucu
R. A. Rosen
G. M. Dobre
J. A. Rogers
D.A. Jackson

Quasi-simultaneous OCT en-face imaging with two different depth resolutions

 

J. Phys. D: Appl. Phys. 36 2003, pp. 1696–1702

 

School of Physical Sciences, Ingram Building, University of Kent, Canterbury, Kent, CT2 7NH

Enquiries: email us

Last Updated: 28/11/2013