This module is not currently running in 2024 to 2025.
This module introduces and develops knowledge in the key area of genomic maintenance. Students will learn how loss of genomic integrity leads to enhanced cancer incidence, and how biological processes and the environment contribute to genetic instability. Cellular mechanisms that lead to cancer incidence, together with those that protect cells from the onset of carcinogenic processes will be reviewed. This module will also examine the use of DNA damaging agents in cancer therapies, reviewing the most recent literature in this field.
Total contact hours: 27
Private study hours: 123
Total study hours: 150
Critical analysis essay (2,500 words, 50%)
Exam (2 hours, 50%)
Academic year 2022/23 examined: Time-Bound Online Assessment
DNA Repair and Mutagenesis, Friedberg et al, ASM Press (Second Edition)
The Biology of Cancer, Weinberg, Garland Science (Second Edition)
See the library reading list for this module (Canterbury)
The intended subject specific learning outcomes. On successfully completing the module students will be able to:
Have a knowledge and understanding of:
Endogenous and exogenous sources of DNA damage and their relationship with cancer incidence.
Key mechanisms involved in maintaining genomic integrity.
The relevance of the biological response to DNA damage to disease incidence and therapy.
Biological investigation of DNA damage and its repair.
The intended generic learning outcomes. On successfully completing the module students will be able to:
Organise information clearly, present information in oral and written form, adapt presentation for different audiences.
Interpret data, marshal of information from published sources, critically evaluate own research and that of others.
Make use of constructive informal feedback from staff and peers and assess own progress to enhance performance and personal skills.
Manage time and workload in order to meet personal targets and imposed deadlines.
Make use of appropriate technology to retrieve, analyse and present scientific information.
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