Events Calendar
May 29
14:00 - 15:00
Dr Chunhui Li, University of Dundee: Functional Optical Coherence Tomography (OCT) development and application – Elastography and Angiography
Physical Sciences colloquia

Optical Coherence Elastography (OCE) and Optical Coherence Angiography (OCTA) are the functional extension of traditional gray-level OCT structural images, which can provide more biomarkers to improve diagnostic accuracy. In this talk, recent study at Dundee on functional OCT development and application are presented. In OCE study, we confirmed a high diagnostic accuracy of OCE imaging in the detection and characterisation of prostate cancer for a large set of biopsy tissues obtained from men suspected to have prostate cancer using transrectal ultrasound (TRUS). The results showed that stiffness of cancer tissue was approximately 57.63% higher than that of benign tissue (Young's modulus of 698.43 ± 125.29 kPa for cancerous tissue versus 443.07 ± 88.95 kPa for benign tissue with OCE. Using histology as a reference standard and 600kPa as a cut-off threshold, the data analysis showed sensitivity and specificity of 89.6% and 99.8% respectively. Corresponding positive and negative predictive values were 99.5% and 94.6% respectively. In OCTA study, we recently demonstrated our newly build flexible OCTA probe and its preliminary results in normal and cyst skin. These new findings suggest that functional OCT are increasingly important in advancing optical imaging system for diagnosis and therapy monitoring.


Ingram Lecture Theatre
United Kingdom
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Contact: Helena Shepherd
School of Physical Sciences


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