Events Calendar
Apr 4
14:00 - 15:30
Professor Barbel Finkenstadt - University of Warwick
Statistics Seminar
Inference for Circadian pacemaking

Title: Inference for Circadian pacemaking

Abstract:

Organisms have evolved an internal biological clock which allows them to temporally regulate and organize their physiological and behavioral responses to cope in an optimal way with the fundamentally periodic nature of the environment. It is now well established that the molecular genetics of such rhythms within the cell consist of interwoven transcriptional-translational feedback loops (TTFLs) involving about 15 clock genes, which generate circa 24-h oscillations in many cellular functions at cell population or whole organism levels. We will present statistical methods and modelling approaches  that address newly emerging large circadian data sets, namely spatio-temporal gene expression in SCN neurons and rest-activity actigraph data obtained from non-invasive e-monitoring, both of which provide unique opportunities for furthering progress in understanding the synchronicity of circadian pacemaking and address implications for monitoring patients in chronotherapeutic healthcare.

Location

Lecture Theatre ,
Chipperfield Building,
University of Kent,
Canterbury,
Kent,
CT2 7PE
United Kingdom
Map

Details

Contact: Maria Kalli
E: M.Kalli-672@kent.ac.uk
SMSAS

 

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Last Updated: 10/01/2012