Research Seminar: OH, the places you'll go! Protein hydroxylation and its role in physiology and disease.
25 May 2017
Dr. Mathew Coleman, Institute of Cancer and Genomic Sciences, University of Birmingham
Tuesday 30th May, 1.00 p.m., Stacey Lecture Theatre 1
Hydroxylation is a relatively poorly-characterised protein modification catalysed by a family of oxygenases that depend on fundamental nutrients and metabolic intermediates for activity. These oxygenases are implicated in several major diseases, including cancer, where their deregulation can have dramatic consequences for cellular homeostasis.
In this seminar I will provide an overview of the history and development of hydroxylation research, followed by some examples of our own work that highlights the prevalence of hydroxylation and its role in fundamental cellular processes including hypoxia, epigenetics, protein synthesis and cell polarity.