Profile

Senior Lecturer in Organic Chemistry

Office: Room 317, Ingram Building
Telephone: (01227) 823521
Email: S.Biagini@kent.ac.uk

Key Administration roles

• Pastoral & Academic Support System (PASS) Tutor for Stages 2 and 3.
• Chair of Board of Examiners (HNC & HND)

Functional Materials Group

Dr Stefano Biagini Publications

Biography

Dr Biagini is a graduate of the University of Exeter (1990), and remained at the same institute to undertake his PhD training under the supervision of Prof Nicholas Turner, in the synthesis of aza-sugar derivatives as potential anti-HIV compounds (1994). Subsequently Dr Biagini joined the group of Prof Michael North at the University of North Wales, Bangor, in collaboration with Prof Vernon Gibson and co-workers at Imperial College, London, investigating novel amino acid monomers for the ROMP process, using the Schrock and Grubbs initiators.
A further postdoctoral position with Prof Susan Gibson at Imperial College, London, led to a successful investigation of olefin cross-metathesis of solid-phase supported amino acids. This was followed by a lectureship at King's College, London, after which Dr Biagini joined the University of Kent.

Research Interests

Dr Biagini’s research interests lie in the synthesis and applications of amino acids and peptide derivatives and these have been centered around the ROMP process, and in developing novel radiopharmaceuticals. This has also led to collaborations with: Dr Simon Holder (Kent) and Dr Nico Sommerdijk (Eindhoven) in supramolecular self-assembly of block co-polymers; Prof Phil Blower (King's College, London) and Prof Steve Mathers (CRUK, St Bartholomew's Hospital, London) in the synthesis of amino acid derivatives with applications in nuclear medicine; and Prof Ian Bruce (Kent) in the area of surface modification of nanoparticles.

• Ring-opening metathesis polymerisations.
• Complex monomer syntheses.
• Block copolymers, self-assembly, properties and applications.
• Radiopharmaceuticals for nuclear medicine applications.
• Unnatural amino acid and peptide syntheses.
• Surface modifications on silica magnetite nanoparticles.

Selected Publications

“Trifluoroacetyl as a protecting group for HYNIC: stability in the presence of electrophiles and application in the synthesis of Tc-99m-radiolabelled peptides”, M. B. Surfraz, R. King, S. J. Mather, S. Biagini and P. J. Blower, Tetrahedron, 2010, 66, 2037-2043.
DOI: 10.1016/j.tet.2010.01.038

 “Technetium-binding in labelled HYNIC-peptide conjugates: Role of coordinating amino acids
M. B. Surfraz, R. King, S. J. Mather, S. Biagini and P. J. Blower, J. Inorg. Biochem., 2009, 103, 971-977. DOI: 10.1016/j.jinorgbio.2009.04.007

“Cryo-Electron Tomography reveals Confined Complex Morphologies from Tripeptide-containing Amphiphilic Double Comb Diblock Copolymers” A. L. Parry, P. H. H. Bomans, S. J. Holder, N. A. J. M Sommerdijk, S. C. G Biagini, Angew. Chem., Int. Ed. Engl, 2008, 47, 8859-8862. DOI: 10.1002/anie.200802834.
Selected by the editors as a Hot Paper contribution.

Cover Picture; Angew. Chem. Int. Ed. 46/2008: DOI: 10.1002/anie.200890233.

 “Copolymerization of Amino-Acid and Amino-Ester Functionalized Norbornenes via Living Ring-Opening Metathesis Polymerization” Stefano C. G. Biagini, Vernon C. Gibson, Matthew R. Giles, Edward L. Marshall, and Michael North, J. Polym. Sci., Part A: Polym. Chem., 2008, 46, 7985-7995. DOI: 10.1002/pola.23098.

“A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions”
M. B. Surfraz, S. Biagini, P. J. Blower, Dalton Trans, 2008, 2920-2922.
DOI: 10.1039/b805110k. Selected by the editors as a Hot Article contribution.

“How do HYNIC-conjugated peptides bind technetium? Insights from LC-MS and stability studies”
R. King, M. B. Surfraz, S. Biagini, P. J. Blower and S. J. Mather, Dalton Trans, 2007,4998-5007.
DOI:10.1039/b705111e. Selected by the editors as a Hot Article contribution.

“Investigation in to the ROMP copolymerisation of peptide- and PEG-functionalised norbornene derivatives.”
S.C.G. Biagini, A. L. Parry, J. Polym. Sci.., Part A: Polym. Chem., 2007, 45, 3178-3190.
DOI: 10.1002/pola.22068.

“Trifluoroacetyl-HYNIC peptides: Synthesis and 99mTc radiolabeling.”
M. B. Surfraz, R. King, S. J. Mather, S. Biagini and P. J. Blower, J. Med. Chem., 2007, 50, 1418-1422.

Teaching

• Organic Chemistry (PS022, CH504)
• Analytical Chemistry (CH604)
• Physical Chemistry (PS021, PS023)
• Forensic Chemistry Projects (CH620)
• Forensic Science (PS301)
• Forensic Science Projects (PS620)
• Convenor for PS022, CH604, CH620 and PS620.